Derivation of human health hazard assessment values for toluene under the Japanese Chemical Substances Control Law

نویسندگان

چکیده

Toluene had been designated as a priority assessment chemical substance under the Japanese Chemical Substances Control Law (CSCL), and result of prioritization, detailed human health hazard was conducted Assessment II. We evaluated its general, reproductive, developmental toxicities, well genotoxicity carcinogenicity, based on information provided by domestic international risk organizations, following values for oral inhalation exposure are proposed. The value 0.223 mg/kg/day calculated from no-observed-adverse-effect level (NOAEL) 312 (equal to an average daily dose 223 mg/kg/day) liver kidney weight increases in 13-week toxicity study rats using uncertainty factor (UF) 1,000 (interspecies variation: 10, intraspecies short test period: 10). 0.1 ppm (0.383 mg/m3) NOAEL 45 continuous 10.7 ppm) toxic effects central nervous system found epidemiological investigations occupational UF 100 (intraspecies 10 severe effect:

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ژورنال

عنوان ژورنال: Fundamental Toxicological Sciences

سال: 2022

ISSN: ['2189-115X']

DOI: https://doi.org/10.2131/fts.9.123